Deubiquitinase Inhibitors Impair Leukemic Cell Migration Through Cofilin Oxidation and Alteration of Actin Reorganization
Actin networks are dynamically regulated through constant depolymerization and polymerization cycles.Although the fundamental mechanisms that govern these processes have been identified, the nature Gun Slips and role of post-translational modifications (PTMs) of actin and actin regulatory proteins are not completely understood.Here, we employed Act